Chronic, intermittent convection-enhanced delivery devices

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Chronic, intermittent convection-enhanced delivery devices

BACKGROUND Intraparenchymal convection-enhanced delivery (CED) of therapeutics directly into the brain has long been endorsed as a medium through which meaningful concentrations of drug can be administered to patients, bypassing the blood brain barrier. The translation of the technology to clinic has been hindered by poor distribution not previously observed in smaller pre-clinical models. In p...

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ژورنال

عنوان ژورنال: Journal of Neuroscience Methods

سال: 2016

ISSN: 0165-0270

DOI: 10.1016/j.jneumeth.2015.11.008